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    Moderna signs $35 million deal with cancer drug developer CytomX

    Shares of California-based CytomX rose more than 50% in extended trading.The firm will get $5 million in prepaid research funding as part of the upfront payment and it is eligible for up to about $1.2 billion in future milestone payments, the companies said in a joint statement. The news comes a month after an experimental cancer vaccine from Moderna based on mRNA technology was shown to work against a type of skin cancer. The deal offers CytomX access to Moderna’s mRNA technology, which has been used to develop COVID-19 vaccines, while Moderna would get access to CytomX’s Probody platform, used in the development of cancer therapies targeting diseased tissues. Moderna said it will also pay tiered royalties to CytomX on global sales of any products which enter the market under the deal. The agreement also provides the biotech company the option to participate in a future equity financing by CytomX.The companies will work together to discover experimental therapies and Moderna will be responsible for human trials and commercial activities of products. An mRNA-based therapy or vaccine works by instructing human cells to produce proteins that can spur the immune system into action. More

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    CME Group to launch 3 metaverse reference rates

    Beginning Jan. 30, CME Group and CF Benchmarks will launch reference rates for Axie Infinity Shards (AXS), Chiliz (CHZ) and Decentraland’s MANA (MANA), the company announced on Jan. 5. The reference rates and indexes are not tradeable products but instead can be used by investors to “price sector-specific portfolios, develop structured products […] and manage price risk around various Metaverse-based projects,” said Giovanni Vicioso, CME Group’s head of cryptocurrency products. Continue Reading on Coin Telegraph More

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    Euro zone producer prices fall m/m as expected in Nov

    The European Union’s statistics office Eurostat said prices at factory gates in the 19 countries sharing the euro fell 0.9% month-on-month for a 27.1% year-on-year rise.The monthly fall was mainly due to a sharp decline in energy prices, which were 2.2% lower in November than in October. A 0.4% monthly fall in prices of intermediate goods helped too.But energy prices were still 55.7% higher in November than a year earlier, accounting for most of the year-on-year rise of the overall producer price index which is an early indication of consumer inflation trends.The European Central Bank wants to keep consumer inflation at 2.0% over the medium term and has been rapidly raising interest rates since the middle of the year to bring price growth, caused by Russia’s invasion of Ukraine, under control. More

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    U.S. labor market strong at end of 2022; trade gap narrows sharply

    WASHINGTON (Reuters) – The number of Americans filing new claims for jobless benefits dropped to a three-month low last week while layoffs fell 43% in December, pointing to a still-tight labor market that could force the Federal Reserve to keep hiking interest rates.Labor market resilience was underscored by other data on Thursday showing private employers hired far more workers than expected last month. The reports suggested the economy ended 2022 on solid footing, despite a raft of layoffs in the technology industry as well as in interest rate-sensitive sectors like finance and housing.The sustained jobs market strength raises the risk that the Fed, engaged in its fastest interest rate-hiking cycle since the 1980s as it tries to dampen demand to tame inflation, could boost its target interest rate above the 5.1% peak the U.S. central bank projected last month and keep it there for a while.”Fed officials are expecting a slowing in the job market given the big increase in interest rates last year,” said Stuart Hoffman, senior economic advisor at PNC Financial (NYSE:PNC) in Pittsburgh, Pennsylvania. “Right now the labor market is too tight for the Fed, and job growth is too strong.”Initial claims for state unemployment benefits decreased 19,000 to a seasonally adjusted 204,000 for the week ended Dec. 31, the lowest level since the end of September, the Labor Department said. Economists polled by Reuters had forecast 225,000 claims for the latest week. Through the volatility of the year-end holidays, claims have remained at very low levels.Unadjusted claims rose only 5,703 to 275,552 last week. There were notable increases in claims in New Jersey, New York, Pennsylvania and Michigan, which offset decreases in Missouri, Texas and Kentucky. Economists speculated that severance packages and still-strong demand for labor, which made it easier for laid-off workers to get another job, were keeping claims low. They also said companies are likely to slow hiring before embarking on layoffs after struggling to find labor during the pandemic.The Labor Department reported on Wednesday that there were 10.458 million job openings at the end of November, which translated to 1.74 jobs for every unemployed person.U.S. stocks were trading lower. The dollar rose against a basket of currencies. U.S. Treasury prices fell.VERY TIGHT LABOR MARKET The Fed last year hiked its policy rate by 425 basis points from near zero to a 4.25%-4.50% range, the highest since late 2007. Last month, it projected at least an additional 75 basis points of increases in borrowing costs by the end of 2023.Minutes of the Fed’s Dec. 13-14 policy meeting, which were published on Wednesday, showed officials noted that the labor market remained “very tight,” with a “few remarking that some business contacts reported that they would be keen to retain workers even in the face of slowing demand for output because of their recent experiences of labor shortages and hiring challenges.”The claims report also showed the number of people receiving benefits after an initial week of aid, a proxy for hiring, dropped 24,000 to 1.694 million in the week ending Dec. 24. The so-called continuing claims had jumped to an 11-month high of 1.718 million in the prior week. Economists were divided on whether this indicated some loosening of labor market conditions or year-end volatility.”Through some of the ups and downs in the series over recent months, filings for both initial claims and continuing claims generally have been coming in at low levels by the standards of recent decades, which is indicative of labor market strength,” said Daniel Silver, an economist at JPMorgan (NYSE:JPM) in New York.A separate report from global outplacement firm Challenger, Gray & Christmas on Thursday showed U.S.-based employers announced 43,651 job cuts in December, down 43% from November. The total was, however, 129% higher compared to December 2021 and was the second-largest monthly number announced in 2022. The bulk of the job cuts were in the technology sector. For the whole of 2022, job cuts increased 13% to 363,824. It was still the second-lowest recorded annual total since Challenger began tracking the series in 1993.A third report showed private payrolls increased by 235,000 jobs last month after rising by 182,000 in November. Economists had expected the ADP National Employment report would show an increase of 150,000 private jobs.The reports were published ahead of the release on Friday of the Labor Department’s more comprehensive and closely watched employment report for December. According to a Reuters survey of economists, nonfarm payrolls are forecast to have advanced by 200,000 jobs. The economy created 263,000 jobs in November.There was more goods news on the economy, from the gross domestic product accounting perspective. A fourth report from the Commerce Department showed the trade deficit narrowed 21.0% to $61.5 billion in November, the lowest level since September 2020. The trade gap contraction, the biggest since February 2009, reflected a slump in goods imports to a 13-month low.While a smaller import bill is a boost to GDP, it is also a sign that domestic demand is cooling amid stiff borrowing costs. Nevertheless, it will offset the weakness in exports. A smaller trade deficit was the largest contributor to the economy’s 3.2% annualized growth pace in the third quarter. Growth estimates for the fourth quarter are as high as a 3.8% rate. “Trade will support fourth-quarter GDP,” said Ryan Sweet, chief economist at Oxford Economics. “Solid economic growth increases the risk that the recession arrives later than our current second-quarter 2023 baseline expectation.” More

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    Marketmind: Fed up? Square up

    (Reuters) – A look at the day ahead in Asian markets from Jamie McGeever.If Asian markets take their cue on Friday from Wall Street’s slump on Thursday, they will likely succumb to a bout of profit-taking on what has been a fairly positive start to the year.But the relative outperformance may not last. The deepening gloom surrounding the Fed and its ‘higher for longer’ stance on interest rates will surely spread to Asia – likely soon, depending on how the latest U.S. employment data pans out.December’s non-farm payrolls report on Friday comes at the end of a week in which surprisingly strong U.S. labor market data have pushed up Fed rate expectations, even though economic activity continues to scream slowdown if not recession. US nonfarm payrolls – actual vs forecasts: https://fingfx.thomsonreuters.com/gfx/mkt/zgvobbqzdpd/PAYROLLS1.jpg 2023 Fed rate cut expectations: https://fingfx.thomsonreuters.com/gfx/mkt/akpeqqdxwpr/2023sofr2.png The Fed’s implied terminal rate, according to ‘SOFR’ rates futures, is back above 5% for the first time in a month, and the amount of rate cuts priced in by the end of the year has fallen to a two-month low of 33 basis points.The S&P 500 and Nasdaq are on track for their fifth consecutive weekly decline – the longest losing streak since April to May last year – marking a significant underperformance versus the rest of the world and Asia in particular.The MSCI Asia ex-Japan index hit a four-month high on Thursday. It, Chinese equities and Hong Kong tech stocks are all firmly in the green for the week – HK tech is up nearly 9% – so traders may think it prudent to square up a little ahead of the payrolls report.Watch foreign exchange markets, too – the dollar is up 1.5% so far this week, on course for its best week since September. Of course, a higher dollar, rising U.S. Treasury yields and tighter U.S. financial conditions is never a good mix for emerging markets. On the local data front, the main event is Taiwan inflation for December.Three key developments that could provide more direction to markets on Friday: – U.S. non-farm payrolls (December)- Fed’s Cook, Bostic, Barkin and George all speak – Euro zone flash inflation (December) More

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    Sandbox Retraces to $0.4352 After A Strong Bullish Momentum

    Sandbox price analysis shows a bullish trend over the last 24 hours, with an average increase of 0.43%. Today’s market began trading at $0.4352 and exploded upward right away. Sandbox has been on an overall uptrend since yesterday, with a total increase of over 0.4 percent since then. The resistance for the SAND/USD pair is currently at $0.443 and the support is at $0.4264. Looking ahead, Sandbox is expected to remain within an uptrend in the near-term future.The Daily Sandbox price analysis reveals strong buying pressure, with the RSI (Relative Strength Indicator) currently at 32.11 this indicates that the market is overbought and is likely to experience a short-term correction soon. With that being said, Sandbox is still expected to remain in an uptrend, as it has done for the past 24 hours.The post Sandbox Retraces to $0.4352 After A Strong Bullish Momentum appeared first on Coin Edition.See original on CoinEdition More

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    Quantum computers may soon breach blockchain cryptography: Report

    Breaching the RSA-2048 algorithm requires, similar to other algorithms in the RSA numbers family, finding the prime factors of a number with 617 decimal digits and 2048 binary digits. Experts estimate that it would take ordinary computers 300 trillion years to break an RSA-2048 encryption key. However, Chinese researchers said in their paper that the encryption could be inversed with a quantum computer with 372 qubits, or a basic unit of information acting as a proxy for computation power.Continue Reading on Coin Telegraph More