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    Pfizer RSV vaccine for infants has ‘generally favorable’ safety data, FDA staff say

    Food and Drug Administration staff said Pfizer’s vaccine that protects infants from respiratory syncytial virus has “generally favorable” safety data.
    The FDA staff made the conclusion ahead of a meeting on Thursday when an advisory panel will discuss whether to recommend full approval of the RSV shot.
    The agency is slated to make a decision on whether to clear the jab in August before RSV season in the fall. 
    Pfizer’s shot is administered to expectant mothers.

    Blood sample for respiratory syncytial virus (RSV) test
    Jarun011 | Istock | Getty Images

    U.S. Food and Drug Administration staff on Tuesday said Pfizer’s vaccine that protects infants from respiratory syncytial virus has “generally favorable” safety data.
    The FDA staff made the conclusion in briefing documents ahead of a meeting on Thursday when a panel of external advisors to the agency will discuss whether to recommend full approval of the RSV shot.

    The advisors will vote on whether Pfizer’s late-stage clinical trial data on the vaccine supports its safety and efficacy. The FDA typically follows the advice of its advisory committees, but is not required to do so.
    The agency is slated to make a decision on whether to clear the shot in August before RSV season in the fall. If approved, Pfizer’s jab would become the world’s first vaccine that protects infants against RSV. 
    RSV usually causes mild, cold-like symptoms. But infants and older adults are particularly vulnerable to having more severe cases.
    Each year the virus kills 6,000 to 10,000 seniors and a few hundred children younger than 5, according to the Centers for Disease Control and Prevention.
    The FDA earlier this month approved an RSV shot from GlaxoSmithKline for adults ages 60 and older.

    The agency is expected to make a decision within weeks on Pfizer’s other RSV shot for that same age group.
    Pfizer’s RSV vaccine that protects infants is administered to expectant mothers in the late second or third trimester of their pregnancy. 
    The single-dose vaccine triggers antibodies that are passed to the fetus, which provides it with protection against RSV from birth through the first six months of life. 
    Along with safety information, the staff also reviewed the vaccine’s efficacy data.
    Pfizer’s trial found the shot was 82% effective at preventing severe disease from RSV in newborns during the first 90 days of life. The shot was about 70% effective during the first six months of the baby’s life.
    Most of the more than 3,000 mothers who received the shot in a phase three trial experienced mild to moderate adverse reactions, according to the FDA staff’s review of data.
    The most common reactions were fatigue, muscle pain, headache and pain at the injection site. Most reactions resolved within three to four days after vaccination, the staff review noted.
    A higher number of premature births occurred among mothers who took the vaccine compared to those who received a placebo, according to the staff review.
    But they said that difference does not appear to be statistically significant. 
    Some of the participants’ children also had low birth weights, the staff review said. 
    The trial reported a total of 18 peripartum fetal deaths, which includes infants who survived briefly after birth and fetuses that died during pregnancy. 
    But the FDA staff said it is unlikely that those deaths are related to Pfizer’s shot. More

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    Homebuilder sentiment pulls out of negative territory for the first time in nearly a year

    Builder confidence in the market for newly built single-family homes rose 5 points to 50 in May, according to the National Association of Home Builders (NAHB)/Wells Fargo Housing Market Index (HMI).
    It’s the fifth straight month of gains and the first reading of builder sentiment since July that wasn’t negative.
    Of the index’s three components, current sales conditions rose 5 points to 56, sales expectations in the next six months increased 7 points to 57, and buyer traffic climbed 2 points to 33.

    Homebuilders are getting a big boost from the lack of existing homes for sale, and that appears to be outweighing some of the challenges they’re facing from financial markets.
    Builder confidence in the market for newly built single-family homes rose 5 points in May to 50, according to the National Association of Home Builders (NAHB)/Wells Fargo Housing Market Index (HMI). It’s the fifth straight month of gains and the first reading of builder sentiment since July that wasn’t negative, which would be a reading below 50. Sentiment stood at 69 in May of last year.

    “New home construction is taking on an increased role in the marketplace because many home owners with loans well below current mortgage rates are electing to stay put, and this is keeping the supply of existing homes at a very low level,” said NAHB Chairman Alicia Huey, a homebuilder from Birmingham, Alabama, in a release.
    Huey noted that builders continue to face challenges to meet the growing demand. While the price of lumber has been falling since March, there are still supply shortages of building materials as well as tightening credit conditions for residential real estate development and construction due to the recent banking crisis and higher interest rates.
    Of the index’s three components, current sales conditions rose 5 points to 56, sales expectations in the next six months increased 7 points to 57, and buyer traffic climbed 2 points to 33.
    Builders are benefiting from a very lean existing home market. New listings in April were down nearly 22% year over year, according to Realtor.com. With mortgage rates now double what they were a year and a half ago, some potential sellers may be reluctant to trade to another home at a higher rate.
    “In March, 33% of homes listed for sale were new homes in various stages of construction. That share from 2000-2019 was a 12.7% average. With limited available housing inventory, new construction will continue to be a significant part of prospective buyers’ search in the quarters ahead,” said Robert Dietz, NAHB’s chief economist.

    Homebuilders also drew more buyers by offering incentives, like buying down mortgage rates. Those, however, appear to be winding down as demand grows.
    The share of builders reducing home prices dropped to 27% in May, down from 30% in April, 31% in February and March, and 36% last November. While just over half of builders are still offering some type of sales incentive, the share is down from 62% last December.
    Regionally, on a three-month moving average, builder sentiment in the Northeast was unchanged at 45. Sentiment in the Midwest rose 2 points to 39. In the South, it increased 3 points to 52, and in the West moved 3 points higher to 41. More

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    These retailers are most at risk for a margin squeeze this earnings season thanks to cautious consumers, heavy promotions

    A consumer sentiment survey of 21,000 shoppers across 27 countries found “affordability” is the number one concern for consumers globally before they make a purchase.
    If retailers have been relying on promotions to win over customers, it could impact their margins when they report earnings in the coming weeks.
    Mall retailers and those who sell soft goods like apparel are most at risk for a promotion-induced margin squeeze, analysts said.

    Shoppers are at the Citadel Outlets in Los Angeles.
    Jonathan Alcorn | Reuters

    Affordability is the number one concern for consumers globally, new data released Tuesday by EY shows.
    The price worries could suggest trouble for retailers that are relying on promotions to win over cost-conscious customers. Those companies could see their margins under pressure when they report earnings over the coming weeks. 

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    In a consumer sentiment survey of 21,000 shoppers across 27 countries, 35% of respondents said “affordability” is now their leading concern when it comes to choosing what to buy, according to EY’s Future Consumer Index. The survey’s respondents cited the answer more than any other concern.
    That’s up 10 percentage points since Oct. 2022, the numbers show. 
    “That’s having knock off effects in terms of what people are shopping for, where they’re making substitutions from national brands to private labels, how they’re thinking about scaling back on things that are not essential to them,” Kristina Rogers, EY Global Consumer Leader, told CNBC in an interview. “And similarly around loyalty. They’re more than willing to go somewhere else if there’s better value elsewhere, if they can do something to reduce costs in their budget.” 
    Retailers are likely to lean on promotions to keep struggling customers buying and are “already trying” to do so, even with the hit they are taking to profits, Rogers said. Compounding the issue is growing research showing a shift in consumption habits, she said.
    In the past when consumers were buying something on sale, they tended to spend the same amount they would have if they bought the item at full price by adding a few extra items to the cart. But these days, some are buying less, Rogers explained.

    “The whole idea is for me to buy more,” said Rogers. “That doesn’t mean I’m going to buy more. It just might mean I come to you and not your competitor… So, you know, I don’t know that helps in the way it might have in the past,” she continued.
    The findings come as major retailers, such as Home Depot, Walmart and Target, are releasing earnings this week.
    The earnings will offer a glimpse into consumer health and how heavily companies have been relying on promotions to keep shoppers limping to the checkout line in the face of persistent inflation and rising debt at sky-high interest rates.
    Retailers that largely sell apparel, shoes or home goods are most likely to see squeezed margins due to promotions this earnings season, according to analysts and research.
    “I think we’ll still hear some hurt from Target. I think Macy’s you might hear some of that come through,” said Jessica Ramirez, a senior analyst at Jane Hali and Associates. “Vans is still coming through some promotions that are likely to hurt them. Victoria’s Secret as well. They’ve been very promotional. And then the hardlines, William Sonoma.”
    Home Depot on Tuesday missed quarterly revenue expectations and cut its full fiscal year guidance for comparable sales and operating margin rate — though it is unclear whether promotions factored into that forecast.
    In a Thursday research note, UBS analysts reported softline promotions increased to 17% in April, a 2 percentage point jump year-over-year. They based it on a statistic they call the “discount factor,” which measures the percentage of goods on sale and the average discount off the original price. Softline retailers are those that sell “soft” goods such as apparel.
    The uptick was driven by increases in both the number and size of discounts, and was accelerated by a month-over-month 0.7 percentage point increase, the note said.
    “Our view is the market underestimates the pressure on industry sales from US consumers’ decreasing ability and willingness to spend on apparel and footwear. We expect sales trends to weaken over the course of 2023,” the note stated. “This is likely a bad sign for Softline retailers’ 1Q23 gross margins.” 

    Annapolis, Maryland, on May 16, 2022
    Jim Watson | AFP | Getty Images

    The bank listed the companies that saw the biggest year-over-year changes in discounts. The public retailers where promotions rose the most are Skechers, American Eagle, Ralph Lauren, The Children’s Place, Under Armour, Nike, Urban Outfitters, Victoria’s Secret, Macy’s and three of Gap’s brands – Banana Republic, Athleta and Old Navy. 
    Retailers and brands that have the largest decreases in discounts year-over-year include Gap’s namesake banner, Lululemon, Nordstrom, Foot Locker and its brand Champs Sports.
    Since mid-2022, softline retailers have been passing inflationary costs onto consumers, but it suspects companies will give up these price gains in a bid to protect market share “as the macro outlook weakens,” UBS said.
    Compared to last year, retailers have some supply chain tailwinds such as reduced freight expenses that are expected to boost margins. But considering the increased promotional environment, it’s not clear if those savings will materialize, said Simeon Siegel, a retail analyst for BMO Capital Markets. 
    “Retailers actually have margin relief this year because last year supply chains were so expensive, but that will be offset by promotion,” Siegel told CNBC. “The question is, is it partially offset? Or does it more than engulf the savings?”
    He pointed to Gap, and how promotions and higher commodity prices shaved five percentage points off of its gross margins in fiscal 2022, even with lower air freight expenses. 
    Siegel expects other apparel mall retailers like Gap are most at risk for promotion-induced margin squeezes this earnings season. 
    Last week, Under Armour missed fiscal fourth-quarter expectations on gross margins because it used steep discounts and promotions to drive higher sales, the retailer’s Chief Financial Officer David Bergman told analysts. The company warned the issue could persist.

    A clearance sale sign is seen at the Gap retail store on September 20, 2022 in Los Angeles, California.
    Allison Dinner | Getty Images

    The analyst Ramirez said the savvier retailers have been selective in the items they choose to promote. They’ve focused on marking down merchandise that’s fallen out of demand, such as home goods, while keeping more coveted items off the discount shelf.  
    “It’s leaning into your consumer and their priorities,” said Ramirez. “Retailers today are much more in tune with the consumer interest and the consumer needs than they were before the pandemic.” 
    Despite repeated concerns over a more cautious consumer that’s echoed on earnings calls and research desks for the last few quarters, Ramirez pointed out those losses haven’t shown up on retailers’ balance sheets too broadly.
    At least not yet. More

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    Target wants shoppers to think of it for groceries as retailer braces for leaner spending

    Target wants to attract grocery shoppers as consumers buy fewer discretionary goods.
    The company has tried to stand out by selling its own unique food and beverage items, raising its fresh food standards and appealing to shoppers seeking convenience.
    The big-box retailer will report earnings on Wednesday.

    About 21% of Target’s annual sales come from the food and beverage category, but its grocery aisles have taken on added importance as shoppers buy fewer discretionary items.
    Melissa Repko | CNBC

    For many Americans, a trip to Target brings to mind a shopping cart filled with throw pillows, makeup or a cute outfit.
    The retailer wants more customers to think of it when checking off the grocery list, too.

    Only 21% of Target’s annual sales came from food and beverage in the most recent fiscal year, according to the company’s financial filings. That’s a sharp difference from rival Walmart, which gets nearly 60% of its annual sales from the grocery aisles.
    Yet as inflation-wary shoppers watch their budgets and focus on needs instead of wants, grocery has gained importance as a driver of foot traffic. Investors will learn this week if Target could help make up for softer sales of apparel, electronics and home goods by selling more boxes of pasta, gallons of milk and cartons of eggs. The company will report earnings before the bell Wednesday.

    Target will post results as the company’s stock has fallen, driven in part by challenging pandemic comparisons and its own inventory missteps. Shares of Target closed Monday at $160.57, down nearly 30% from its 52-week high.
    The big-box retailer also hopes by drawing shoppers for essentials like gallons of milk, it can nudge purchases of discretionary items that shoppers otherwise would not have bought.
    “It’s actually a gateway to the rest of the store,” Chief Food and Beverage Officer Rick Gomez said in an interview with CNBC. “It drives traffic to the store. It drives traffic to our site. And then while they’re picking up what they need food- and beverage-wise, they’ll browse through the rest of the store and maybe pick up a few things at Ulta [Beauty at Target] or a few things in apparel.”

    A ‘Tarzhay’ spin on groceries

    On a recent trip to a Minneapolis area grocery store, Gomez surveyed displays of colorful fruits and vegetables. Nearby, shoppers could order freshly sliced turkey at the store’s full deli counter or order a custom birthday cake at a bakery.
    The store captures Target’s grocery ambitions, even though it offers a much larger mix of food than many of the retailer’s other stores. The retailer’s stores vary in size and so do its grocery departments.
    Since stepping into his food and beverage role a little over two years ago, Gomez has overseen Target’s efforts to raise the quality of the grocery department. He said that began with some tough truths: Customers weren’t satisfied.
    “We were doing focus groups and one of our guests said, ‘You know, I know Target sells food and beverage, but it kind of feels like an afterthought. It feels a little bit like a bolt-on. It doesn’t have ‘Tarzhay magic’ that the rest of the store has,” Gomez said.
    “It was a little disheartening, but rather than get frustrated and get disappointed about it, we said, ‘You know what, let’s use that as a rallying cry,'” he said.
    Target struggled with out-of-stock items in the department, even before the pandemic walloped the supply chain, he said. Fruits and vegetables weren’t always fresh. The grocery department didn’t capture a celebratory or seasonal flair like other parts of the store.
    Target can now offer more reliability with a new distribution center in Maryland that opened in October, he said. It hired more employees with grocery expertise and raised its produce specifications to lengthen freshness, improve taste and boost presentation, such as making sure avocados are a consistent size.
    He said that Target has added more items to Good & Gather, its primary private label grocery brand that launched in 2019 and to Favorite Day, a line of snacks and desserts that debuted in 2021.
    It has riffed off the model of Trader Joe’s by coming up with creative items that can’t be found elsewhere, such as s’mores trail mix and an avocado toast-flavored chopped salad kit. Some items are seasonal, too, like a peach jelly bean-flavored whipped cream for Easter.
    Gomez credited those changes and others for fueling sales gains. In each of the past two fiscal years, Target has had double-digit sales growth in the food and beverage category.
    The segment’s sales as a percentage of Target’s overall annual revenue has stayed relatively flat, but its total sales have spiked. Food and beverage sales totaled $22.9 billion in the fiscal year that ended in January, up about 52% from $15 billion in the year that ended in late January 2020.
    Target’s grocery sales matter more as shoppers pull back in other areas. Company leaders said at an investor meeting in January that the retailer took action to address the budget sensitivity they were seeing from consumers. After its aggressive actions to clear through excess inventory, the company stocked up more on food and essentials.
    It had about 13% less inventory in discretionary categories compared with a year ago at the end of the fiscal fourth quarter. Target also said it would offer more items at lower price points, such as $3, $5, $10 and $15.

    Grocery competition gets tougher

    Competition for grocery shoppers has heated up, especially as consumers stretch their budgets. Discounters like Aldi, Lidl and Dollar General are opening more stores, while warehouse clubs like Costco, BJ’s Wholesale and Walmart-owned Sam’s Club have reeled in more members by offering cheaper gas and bulk sizes. Meanwhile, Kroger wants to get bigger by acquiring Albertsons.

    Target is the fourth-largest grocer in the U.S., with 5.3% of market share in 2022, according to market researcher Euromonitor. That data does not include online grocery sales, which Target has grown through curbside pickup and its home delivery service, Shipt.
    The retailer doesn’t attract as many shoppers doing a big weekly grocery trip as its rivals, said Michael Lasser, a retail analyst for UBS. Yet he said it caters to convenience by selling clothing and toys, and offers value with its expanded private label brands.
    “Target has increased its relevance in grocery over the past several years,” he said. “The shopper can get more of its needs satisfied at Target today versus in the past.”
    But leaning too much into grocery is a risk, Lasser said. That department drives lower margins than other categories — plus, its cheap chic spin on home goods, apparel and more is a key part of what draws shoppers to its website and stores.
    Karen Short, a retail analyst for Credit Suisse, said as a shopper, she doesn’t buy fresh foods from Target. She said it can’t offer the same freshness of grocers that sell more produce and turn over berries and bagged salads more quickly.
    If the company expands its produce selection, however, she added, it risks tossing more into the garbage bin.
    “That’s Target’s permanent dilemma,” she said.
    But Target’s Gomez said the company does have the velocity for fresh food: “The volume is there. The traffic is there.”
    Target has another issue in building its grocery business relative to Walmart, Short added. She said over the past few quarters, Target has lost some of the shoppers and store visits it gained during the pandemic as consumers stressed affordability over convenience. She said it has a perception problem, as some link the retailer’s flair with higher prices.
    In the Minneapolis area, prices of staples at Target were nearly in line with a Walmart less than two miles away. On most of those items, such as a dozen eggs, a gallon of milk and a box of pasta, Target was about 5 or 10 cents more, according to a CNBC analysis.
    On a trip to a Minneapolis store with CNBC, Gomez mentioned a recent advertising campaign about “affordable joy.” He pointed out simplified displays at the end of aisles, which advertise a single low price for items like boxes of cereal.
    Value goes beyond price too, Gomez said.
    “When times are tough and you’re paycheck to paycheck, you can’t afford to buy food that nobody eats,” he said. “So it’s really important to us that we offer value which is a good price, but also really good quality.”
    It’s unclear if Target’s effort to bill itself as a budget-friendly grocer will resonate with consumers.
    Prices are top of mind for Megan Harvey, 29, of New York City. She enjoys visiting Target and belongs to its loyalty program, Circle. Yet she and her boyfriend, Ben Horansky, 29, don’t buy groceries there.
    Instead, Harvey said she typically goes to the retailer’s store in her Upper East Side neighborhood to buy beauty items, such as facewash, or home goods like bath towels. On Sunday, for example, she stopped in and bought a pack of razors.
    Over the past three months, Harvey said she’s made fewer Target visits to limit the temptation of coming in for two items and leaving with 12. The couple decided where to grocery shop after tracking local grocers’ prices on a spreadsheet.
    “Target is just not the first place that jumps to mind when I think of grocery shopping,” Horansky said. But he said he may add it to the price spreadsheet and see how it stacks up.
    Correction: Target’s food and beverage sales were $22.9 billion in the fiscal year that ended in January, and $15 billion in the prior year. A previous version of this story misstated those figures. More

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    Horizon Therapeutics stock plunges on report FTC is preparing to block Amgen deal

    Horizon Therapeutics’ stock plunged after a report that the Federal Trade Commission is preparing to file a lawsuit to block the biotech company’s $27.8 billion sale to Amgen. 
    The FTC could sue to block the acquisition as soon as Tuesday, Bloomberg reported, citing an unnamed source.
    The deal is a bid to strengthen Amgen’s drug portfolio as it prepares to face several patent expirations for key treatments over the next decade.

    Robert Galbraith | Reuters

    Horizon Therapeutics’ stock price plunged more than 17% in premarket trading Tuesday after a report that the Federal Trade Commission is preparing to file a lawsuit to block the biotech company’s $27.8 billion sale to Amgen. 
    The FTC could sue to stop the acquisition as soon as Tuesday, Bloomberg reported, citing an unnamed source.

    An Amgen spokesperson told CNBC the company isn’t aware of any decision made by the FTC. Representatives for Horizon Therapeutics did not immediately respond to a request for comment from CNBC. The FTC declined to comment.
    The two drugmakers said in February that the FTC sent them a second request for information about the acquisition as part of the agency’s review of the deal. 
    Thousand Oaks, California-based Amgen struck the deal to buy Horizon Therapeutics in early December and said it expected to complete the sale in the first half of this year. 
    The move was a bid to strengthen Amgen’s drug portfolio as it prepares to face several patent expirations for key treatments over the next decade.
    That includes a patent for a medicine that treats psoriasis, an autoimmune condition that causes inflammation of the skin.

    CNBC Health & Science

    Read CNBC’s latest global health coverage:

    Horizon, which is based in Ireland, would beef up Amgen’s drug offerings with treatments for rare, autoimmune and severe inflammatory diseases. 
    Horizon carries two fast-growing drugs, the thyroid eye disease treatment Tepezza and the gout medicine Krystexxa. 
    Sen. Elizabeth Warren, D-Mass., in January expressed concern about the deal’s potential impact on competition in the drug market. 
    The acquisition and the then-proposed merger of Indivior and Opiant could “cause further price increases on lifesaving drugs and prevent affordable alternatives from entering the market,” Warren wrote in a letter to FTC Chair Lina Khan and two commissioners at the agency.
    She called on the FTC to “heavily scrutinize” the two deals. The Indivior and Opiant deal later closed. More

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    U.S. Virgin Islands issued subpoena to Elon Musk in Jeffrey Epstein lawsuit

    The U.S. Virgin Islands issued a subpoena to Tesla boss Elon Musk seeking documents for that government’s lawsuit against JPMorgan Chase.
    The Virgin Islands is suing JPMorgan over sex trafficking by the bank’s late longtime customer Jeffrey Epstein.
    The U.S. territory is suing JPMorgan for allegedly enabling and benefiting from Epstein’s trafficking of young women to his private island in the Virgin Islands to be abused by him and others.
    JPMorgan CEO Jamie Dimon is due to be deposed in the case on May 26.

    Electric car maker Tesla CEO Elon Musk meets with French Minister for the Economy and Finances Bruno Le Maire on the sidelines of the 6th edition of the “Choose France” Summit at the Chateau de Versailles, outside Paris on May 15, 2023.
    Ludovic Marin | Pool | Via Reuters

    The U.S. Virgin Islands issued a subpoena to Tesla CEO Elon Musk seeking documents for that government’s lawsuit against JPMorgan Chase over sex trafficking by the bank’s late longtime customer Jeffrey Epstein, a court filing revealed Monday.
    That filing said the Virgin Islands has tried unsuccessfully to serve Musk with the subpoena, which was issued on April 28, because of suspicion that Epstein “may have referred or attempted to refer” Musk as a client to JPMorgan.

    The U.S. territory asked Manhattan federal court Judge Jed Rakoff in the filing to allow it to serve Musk with the subpoena for the documents with Tesla’s registered agent.
    That subpoena demands Musk turn over any documents showing communication involving him, JPMorgan and Epstein, as well as “all Documents reflecting or regarding Epstein’s involvement in human trafficking and/or his procurement of girls or women for consensual sex.”
    The Virgin Islands is suing JPMorgan for allegedly enabling and benefiting from Epstein’s trafficking of young women to his private island in the territory to be abused by him and others.
    JPMorgan denies the government’s claims, which are mirrored in a separate pending civil lawsuit in Manhattan federal court by a woman who says Epstein sexually abused her. JPMorgan CEO Jamie Dimon is due to be deposed for both lawsuits beginning on May 26.
    A May 4 court filing by the Virgin Islands revealed the government had issued a similar subpoena for documents to Google co-founder Larry Page, and that it likewise was having difficulty locating Page.

    And the territory previously issued subpoenas to Page’s fellow Google co-founder Sergey Brin, former Disney executive Michael Ovitz, Hyatt Hotels executive chairman Thomas Pritzker and Mort Zuckerman, the billionaire real estate investor.
    In Monday’s filing, the Virgin Islands said, “Upon information and belief, Elon Musk — the CEO of Tesla, Inc., among other companies — is a high-net-worth individual who Epstein may have referred or attempted to refer to JPMorgan.”
    The government said that it had hired an investigative firm to try to locate an address from Musk, and also contacted one of his lawyers.
    That lawyer in past federal cases has waived the requirement of him being personally served with legal documents, according to the filing.
    “The Government contacted Mr. Musk’s counsel via email to ask if he would be authorized to accept service on Mr. Musk’s behalf in this matter but did not receive a response confirming or denying his authority,” the filing said.
    CNBC has reached out to request comment from Musk. In addition to being CEO of Tesla, Musk is head of SpaceX and owner of Twitter.
    In 2018, Epstein told The New York Times writer James Stewart that he had been advising Musk after the Securities and Exchange Commission opened a probe into Musk’s comments about taking the company private.

    A video still from the NBC archive showing Donald Trump talking with Jeffrey Epstein at a party in Mar-A-Lago from 1992.

    When the Times reached out to Tesla for comment, the company strongly denied that claim, saying, “It is incorrect to say that Epstein ever advised Elon on anything.” Epstein had predicted to Stewart that “everyone at Tesla would deny talking to him or being his friend,” according to an article about their interview.
    Epstein, a former friend of Donald Trump Bill Clinton and Prince Andrew of Britain, was a customer of the bank from 1998 through 2013. In 2008, he pleaded guilty to a state charge in Florida of soliciting sex from an underage girl.
    Epstein killed himself in a Manhattan jail in August 2019, a month after being arrested on child sex trafficking charges.
    — Additional reporting by CNBC’s Lora Kolodny More

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    Universal flu vaccine based on mRNA tech to be tested by National Institutes of Health

    NIH is enrolling patients in an early stage clinical trial to test a universal flu vaccine based on mRNA technology.
    The technology is behind Moderna’s and Pfizer’s widely used Covid vaccines.
    Scientists hope the vaccine will protect against a wide variety of flu strains and provide long-term immunity so people do not have to receive a shot every year.  

    A woman receives a booster dose of the Moderna coronavirus disease (COVID-19) vaccine at a vaccination centre in Antwerp, Belgium, February 1, 2022.
    Johanna Geron | Reuters

    Patients are now enrolling in an early stage clinical trial to test a universal flu vaccine based on messenger RNA technology, the National Institutes of Health announced Monday. 
    Scientists hope the vaccine will protect against a wide variety of flu strains and provide long-term immunity so people do not have to receive a shot every year.  

    Messenger RNA, or mRNA, is the technology behind Moderna’s and Pfizer’s widely used Covid vaccines. NIH played a crucial role in developing the mRNA platform used by Moderna.  
    “A universal flu vaccine could serve as an important line of defense against the spread of a future flu pandemic,” Dr. Hugh Auchincloss, acting director of National Institute of Allergy and Infectious Diseases, said in a statement Monday.
    The universal flu vaccine trial will enroll up to 50 healthy people ages 18 through 49 to test whether the experimental shot is safe and produces an immune response, according to NIH. 
    The study will also include participants who receive a quadrivalent flu vaccine, which protects against four strains of the virus, to compare the experimental universal shot to those currently on the market. 
    The universal shot was developed by researchers at the National Institute of Allergy and Infectious Diseases. The clinical trial is enrolling volunteers at Duke University in Durham, North Carolina.

    The current generation of flu vaccines provide important protection against hospitalization but the effectiveness of the shots can vary widely from year to year. 
    Scientists right now have to predict months in advance which flu strains will dominate so vaccine manufacturers have time to produce the shots ahead of the respiratory virus season. 
    The dominant flu strains can change between the time when experts select the strains and the manufacturers roll the shots out. In some seasons, the shots are not matched well to the circulating strains and are less effective as a consequence. 
    Flu vaccines reduce the risk of illness by 40% to 60% when they are well matched against the circulating strains, according to the Centers for Disease Control and Prevention. But in some years the the vaccines’ effectiveness has been as low as 19% because the shot was not well matched.
    Flu killed between 12,000 and 52,000 people annually in the U.S. from 2010 to 2020 depending the circulating strains and how well matched the shots were, according to the CDC. More

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    A pair of sports betting deals has the gaming industry asking, ‘Who’s next?’

    Fanatics’ splashy $150 million acquisition of PointsBet’s U.S. business wasn’t the only deal in gambling in recent days — and it could be a sign of more to come.
    Aristocrat agreed to buy NeoGames at $29.50 a share, a 130% premium to NeoGames’ closing price Friday.
    Fanatics executive Matt King sees more consolidation on the way, but not at sky-high prices.

    Fanatics founder & CEO Michael Rubin at his office in downtown NYC, Dec. 7, 2022.
    The Washington Post | Getty Images

    Fanatics’ splashy $150 million acquisition of PointsBet’s U.S. business wasn’t the only deal in gambling in recent days — and it could be a sign of more to come.
    Fanatics on Sunday announced it has agreed to buy PointsBet’s U.S. assets, a long-rumored tie-up. Fanatics CEO Michael Rubin previously vowed to launch sports betting operations in every state where it’s legal, except New York.

    Buying PointsBet gives Fanatics market access in New York, along with some 14 other states, and importantly its iGaming, or online casino games, business in Michigan.
    For Fanatics, the deal really pays off when it comes to upfront licensing fees it would need to pay in new states.
    “We’re really able to save tens of millions of dollars worth of upfront license fees by leveraging PointsBets footprint versus going at it with a new footprint,” said Matt King, Fanatics CEO of Betting and Gaming, on Monday.
    King also said the cost to enter new markets has declined between 40% and 50% compared to where it was roughly three to five years ago.

    Now compare that to another blockbuster deal in the sector: the $1.2 billion acquisition of NeoGames by Aristocrat. The deal, announced Sunday, was for $29.50 a share, marking a 130% premium to NeoGames’ closing price Friday.

    Aristocrat is a global leader in attention-getting slot machines. With its purchase of NeoGames, it’s declaring its intent to compete in online lottery, casino and sports betting.
    As Jeffries gaming analyst David Katz wrote in a note Sunday night, “[NeoGames] and the digital gaming group in general, is undervalued by the US market at present levels.” Still, he doesn’t expect higher valuations in the near future.
    Just as importantly, according to Katz, the recent deals raise the question of, “Who’s Next?”
    As the buzz over mergers and acquisitions dominates at gaming conferences, speculation has fallen on SportRadar, a global sports data provider, as a potential takeover target, as well as Gambling.com, an affiliate business that provides media content to funnel new depositors toward gaming operators.
    Rush Street Interactive, another frequent target of acquisition speculation as of late, is working to flex its muscle as an iGaming operator first, sports betting house second.
    At the SBC Summit, a top sports gambling conference, last week CNBC asked RSI CEO Richard Schwartz whether he’s entertaining offers.
    “We have an obligation to shareholders and to get the best return we can. And so we’re always open to evaluate opportunities,” he said, before highlighting the reasons why RSI would be attractive.

    Fanatics’ King agrees more consolidation is likely on the way.
    “There really is no new capital kind of coming into this category,” he said. “Anybody without a sustainable business model is going to be ripe for an acquisition.”
    But don’t expect sky-high prices when it comes to gaming acquisitions, King said.
    “I think certainly people’s price expectations have started to reflect reality,” he added.
    — CNBC’s Jessica Golden contributed to this report. More